Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells

February 2018 in “ Archives of Pharmacal Research ”

Jae Hong Seo, Silvia Yumnam, Kwang-Yong Jeong, Sun Yeou Kim

finasteride melanogenesis melanocytes melanoma cells adenylate cyclase hyperpigmentation disorders melanin production Propecia

TLDR Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.

A study from 5 years ago found that Finasteride can inhibit melanogenesis in melanocytes and melanoma cells by regulating the adenylate cyclase enzyme, potentially offering a treatment option for hyperpigmentation disorders and melanoma. The drug was found to decrease melanin production without causing harm to the cells. However, further research is needed to determine the safety and toxicity of the drug, especially at high doses.

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research Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells

11 citations, February 2018 in “Archives of Pharmacal Research”

Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.

Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells

Research cited in this study

research A Review of Medical and Surgical Treatment Options for Androgenetic Alopecia

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

research Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

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research Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells