TLDR The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.
The study investigated the role of the palmitoylation enzyme DHHC13 in hair and skin differentiation using Zdhhc13-deficient mice. These mice exhibited cyclic alopecia, poor hair anchoring, and abnormal epidermal cornification, leading to impaired skin barrier function and hyperkeratosis. The absence of cornifelin, a substrate of DHHC13, in the hair and skin of these mice suggested its crucial role in maintaining hair and skin integrity. The findings highlighted the importance of DHHC13-mediated palmitoylation in normal hair and skin structures, with cornifelin being a key component.
8 citations,
March 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” The 14-3-3σ gene is essential for preventing hair loss.
375 citations,
February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
59 citations,
May 2017 in “Scientific reports” ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.
7 citations,
September 2017 in “Scientific Reports” Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.
81 citations,
April 2009 in “Journal of Investigative Dermatology” Hair shedding is an active process that could be targeted to treat hair loss.
7 citations,
November 2014 in “Histochemistry and Cell Biology” The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
176 citations,
August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.
