Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

    June 2015 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Kai-Ming Liu, Yi–Ju Chen, Li-Fen Shen … Yuan-Tsong Chen
    Studysummary This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.
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    Research cited in this study 5

    1. Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase PLoS Genetics · 2010
    2. 14-3-3σ Is Required for Club Hair Retention ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    3. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    4. The Hair Cycle Journal of Cell Science · 2006
    5. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002