Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

    November 2015 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Kai-Ming Liu, Yi–Ju Chen, Li-Fen Shen, Amir Haddad, I-Wen Song, Liying Chen, Yu‐Ju Chen, Jer‐Yuarn Wu, J. J. Yen, Yuan-Tsong Chen
    TLDR The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.
    The study investigated the role of the palmitoylation enzyme DHHC13 in hair and skin differentiation using Zdhhc13-deficient mice. These mice exhibited cyclic alopecia, poor hair anchoring, and abnormal epidermal cornification, leading to impaired skin barrier function and hyperkeratosis. The absence of cornifelin, a substrate of DHHC13, in the hair and skin of these mice suggested its crucial role in maintaining hair and skin integrity. The findings highlighted the importance of DHHC13-mediated palmitoylation in normal hair and skin structures, with cornifelin being a key component.
    Discuss this study in the Community →

    Cited in this study

    2 / 2 results