TLDR The 14-3-3σ gene is essential for preventing hair loss.
The study found that the 14-3-3σ gene was essential for retaining club hair in hair follicles. Mice with a mutation in this gene (Er/+) showed cyclic alopecia starting around postnatal day 13, with symptoms including hair loss and regrowth. Histological analysis indicated that these mice had thicker infundibular walls, dilated and plugged follicular ostia, and hyperplastic sebaceous glands. The hair shafts had weakened anchorage due to defective club hair structure, fewer anchoring protrusions, and abnormal desmosomal junction components. The results suggested that 14-3-3σ was crucial for the physiology of companion cells that anchor the club hair, and its deficiency led to hair loss. Further research was needed to understand the gene's role in companion cell function and differentiation.
81 citations,
April 2009 in “Journal of Investigative Dermatology” Hair shedding is an active process that could be targeted to treat hair loss.
107 citations,
September 2002 in “Journal of Investigative Dermatology” Researchers found that hair shedding happens mostly when new hair is growing and involves a unique process.
139 citations,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” K6hf is a unique protein found only in a specific layer of hair follicles.
Protein profiling of forehead skin can help distinguish between frontal fibrosing alopecia and androgenetic alopecia.
16 citations,
June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.
11 citations,
May 2012 in “Genesis” Bmpr2 and Acvr2a receptors are crucial for hair retention and color.
16 citations,
August 2003 in “Journal of The American Academy of Dermatology” Nitrogen mustard was not very effective for hair regrowth in alopecia areata and has potential skin cancer risk.
24 citations,
November 2009 in “Pharmaceutical Development and Technology” Transcutol P best increases Finasteride absorption for hair loss treatment.
