A Pair of Transmembrane Receptors Essential for the Retention and Pigmentation of Hair

The study identified the transmembrane receptors Bmpr2 and Acvr2a as crucial for hair retention and pigmentation. Using genetically modified mice, researchers found that the absence of these receptors led to cyclic alopecia, characterized by dense hair growth during anagen and complete hair loss during catagen, as well as gray hair due to impaired melanosome maturation. The findings highlighted the importance of BMP signaling in hair follicle development, cycling, and melanogenesis, suggesting potential therapeutic targets for hair loss and pigmentation disorders.