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community Experience with CB (Breezula)?

4 upvotes 6 years ago

CB 03 01 (Breezula) was tried for hair loss but showed no significant improvement, with issues in dissolving and application. Finasteride and dutasteride remain the most effective treatments, while minoxidil is also used; CB's effectiveness is questioned, and topical alternatives like bicalutamide are considered.

community Canadians, is CBSA seizing anageninc RU58841 powder?

1 upvotes 1 month ago

The conversation discusses the successful receipt of RU58841 powder in Canada, with no reported issues from a user in British Columbia. The original poster is curious about potential seizures by CBSA but hasn't purchased it yet.

community New Jersey doctor offers new kind of hair loss treatment. Here's how it works. - CBS New York

in Treatment 49 upvotes 1 year ago

Dutasteride mesotherapy is discussed as a hair loss treatment, with opinions on its effectiveness compared to oral dutasteride. The treatment is noted for being expensive, potentially painful, and more popular in Europe, with some users questioning its advantages over traditional methods.

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Research

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research Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice

19 citations , July 2015 in “Journal of inherited metabolic disease”

This study observed that while betaine supplementation decreases total homocysteine and increases methionine levels in a mouse model of CBS deficiency, it is not as effective as methionine restriction in reversing associated phenotypes.

Cystathionine Beta-Synthase-Deficient Mice Thrive on a Low-Methionine Diet

research Cystathionine β‐synthase‐deficient mice thrive on a low‐methionine diet

28 citations , November 2013 in “The FASEB journal”

In this study, a low-methionine diet significantly improved the health and physical traits of cystathionine β-synthase-deficient mice, contrasting with negative effects on mice with partial deficiency.

The Effect of Dietary Modulation of Sulfur Amino Acids on Cystathionine Beta Synthase–Deficient Mice

research The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice

14 citations , November 2015 in “Annals of the New York Academy of Sciences”

This review discusses dietary manipulation strategies in a mouse model of CBS deficiency and reports no new results; the authors emphasize the importance of understanding gene-diet interactions.

research Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

7 citations , March 2022 in “The FASEB journal”

This study observed that mice with a whole-body deficiency of Cystathionine-β-synthase developed severe hyperhomocysteinemia and related mild symptoms without increased mortality, indicating HHCy may not directly cause end organ damage.

research Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

5 citations , September 2018 in “International journal of genomics”

This study found that keratin damage in mammals and birds can result from N-homocysteinylation, reducing keratin solubility and indicating significant protein modification through genetic or nutritional disruptions in homocysteine metabolism.

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