Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

March 2021 in “ Biomolecules & therapeutics ”

Youn Kyung Choi, Jingoo Kang, Jin Won Hyun, Young Sang Koh, Jihoon Kang, Chang‐Gu Hyun, Keun‐Byoung Yoon, Kwang-Sik Lee, Chun Mong Lee, Tae Yang Kim, Eun-Sook Yoo, Hee‐Kyoung Kang

myristoleic acid anagen phase Wnt/β-Catenin pathway ERK pathway dermal papilla cells autophagy DPC proliferation G2/M phase autophagosome formation phosphorylation alopecia MA hair growth phase Wnt pathway ERK DPCs cell recycling cell division hair loss

TLDR Myristoleic acid helps hair growth by boosting cell growth and recycling processes in hair follicle cells.

In 2021, a study was conducted to investigate the effects of Myristoleic Acid (MA) on hair growth. The research found that MA promotes the anagen phase of hair growth by activating the Wnt/β-Catenin and ERK pathways in Dermal Papilla Cells (DPCs) through a process called autophagy. MA was found to increase DPC proliferation, stimulate the G2/M phase of the cell cycle, and induce autophagosome formation. It also increased the phosphorylation levels of Wnt/β-catenin proteins and the levels of phospho-extracellular signal regulated kinases (ERK), leading to changes in protein expression levels and further DPC proliferation. The study concluded that MA could potentially be used as a treatment for hair loss conditions such as alopecia.

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