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Glossary G2 phase

part of cell cycle ensuring DNA is ready for division

The G2 phase is a part of the cell cycle that occurs after DNA replication (S phase) and before cell division (mitosis). During this phase, the cell checks for DNA damage and ensures all the genetic material has been accurately replicated, while also producing proteins and organelles needed for cell division. This phase is crucial for maintaining genetic stability and preparing the cell for successful division.

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research 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis

18 citations , December 2016 in “European journal of pharmacology”

In this study, 12-Chloracetyl-PPD showed anti-cancer activity by inhibiting cancer cell viability and inducing apoptosis through reactive oxygen species production without harming normal cells.

research The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells

9 citations , June 2020 in “BMC Molecular and Cell Biology”

This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.

research Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

8 citations , February 2021 in “Biomolecules & therapeutics”

This study found that myristoleic acid promotes dermal papilla cell proliferation and anagen signaling through autophagy, cell cycle progression, and activation of the Wnt/β-catenin and ERK pathways.

research Perspective Chapter: Appraisal of Paclitaxel (Taxol) Pros and Cons in the Management of Cancer – Prospects in Drug Repurposing

1 citations , January 2023 in “IntechOpen eBooks”

This review explores the advantages and drawbacks of the anticancer drug paclitaxel, noting its effectiveness in combination with cisplatin for breast cancer survival, its potential for treating non-cancer conditions, and the mechanisms behind its resistance.

research Exploring the Role of Uc-Msc-Derived Exosomes in Boosting Hhdpcs Proliferation for Hair Growth Via Akt Activation

January 2024

In this study, human umbilical cord mesenchymal stem cell-derived exosomes were found to promote the growth of human hair dermal papilla cells, partly by enhancing AKT-dependent signaling pathways, suggesting a potential role in treating hair loss.

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