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GlossaryG2 phase

part of cell cycle ensuring DNA is ready for division

The G2 phase is a part of the cell cycle that occurs after DNA replication (S phase) and before cell division (mitosis). During this phase, the cell checks for DNA damage and ensures all the genetic material has been accurately replicated, while also producing proteins and organelles needed for cell division. This phase is crucial for maintaining genetic stability and preparing the cell for successful division.

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research Downregulation of Sonic Hedgehog Signaling Induces G2 Arrest in Genital Warts

4 citations , December 2022 in “Skin Research and Technology”

Reduced Sonic hedgehog signaling leads to increased HPV replication and wart formation.

research G2 Stem Cells Orchestrate Time-Directed, Long-Range Coordination of Calcium Signaling During Skin Epidermal Regeneration

4 citations , October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

G2 stem cells control calcium signaling for skin regeneration.

research Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

8 citations , March 2015 in “Molecular Medicine Reports”

Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated With Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Morroniside Regulates Hair Growth and Cycle Transition via Activation of the Wnt/β-Catenin Signaling Pathway

25 citations , September 2018 in “Scientific Reports”

Morroniside may help hair grow and stay in its growth phase by affecting certain cell signals.

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 5 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community 10 months on dutasteride. Lost about half of my hair density. Losing 150-250 hairsevery day

in Finasteride/Dutasteride 70 upvotes 1 year ago

User experienced significant hair loss after adding dutasteride to their finasteride and minoxidil regimen. They plan to revert to finasteride only due to lack of improvement.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.