Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation

October 2022 in “ Journal of dermatological science ”

Liuying Hu, Shun Kimura, Masatoshi Haga, Sayo Kashiwagi, Kyoko Takagi, Takashi Shimizu, Tsuyoshi Ishii, Manabu Ohyama

panthenyl ethyl ether tocopherol acetate pyridoxine PPT Placental growth factor PlGF VEGFR-1 hair shaft elongation hair matrix cell proliferation dermal papilla cells VEGFR-1 inhibitor PlGF neutralizing antibodies Vitamin B5 derivative Vitamin E acetate Vitamin B6

TLDR Certain vitamins and their derivatives can help hair grow longer by activating specific growth signals.

The study found that a combination of three vitamins and their derivatives, panthenyl ethyl ether, tocopherol acetate, and pyridoxine (collectively referred to as PPT), significantly promoted hair shaft elongation in a mouse vibrissa hair follicle organ culture model. PPT treatment enhanced hair matrix cell proliferation by 1.9-fold and upregulated Placental growth factor (Plgf) by 1.6-fold. The promotive effect on hair growth and increase in VEGFR-1 phosphorylation achieved by PPT was diminished by PlGF neutralizing antibodies and a VEGFR-1 inhibitor. PPT also increased PlGF secretion in cultured human dermal papilla cells. The study concluded that PPT promoted hair shaft elongation by activating PlGF/VEGFR-1 signalling. However, the exact mechanism of how PPT upregulates PlGF remains unclear. The study also acknowledged limitations such as not assessing the long-term effect of PPT and not evaluating its clinical efficacy for male and female pattern hair loss.

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