Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia

    December 2023 in “ Scientific Reports ”
    Mi Hee Kwack, Ons Ben Hamida, Min Kyu Kim … Young Kwan Sung
    Studysummary In this study, researchers successfully established immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia patients, observing distinct gene expression, androgen receptor levels, and hair follicle growth effects between these regions, which may help advance hair loss research and therapeutic development.
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    Research cited in this study 28

    1. TERT/BMI1-Transgenic Human Dermal Papilla Cells Enhance Murine Hair Follicle Formation In Vivo Journal of Dermatological Science · 2022
    2. Expression Level of Leucine-Rich Repeat Containing 15 Regulates Characteristics of Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2020
    3. HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation International Journal of Molecular Sciences · 2019
    4. Overexpression of Alkaline Phosphatase Improves the Hair-Inductive Capacity of Cultured Human Dermal Papilla Spheres Journal of Dermatological Science · 2019
    5. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    6. Establishment and Characterization of Five Immortalized Human Scalp Dermal Papilla Cell Lines Biochemical and Biophysical Research Communications · 2018
    7. SFRP2 Augments Wnt/β-Catenin Signalling in Cultured Dermal Papilla Cells Experimental Dermatology · 2016
    8. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    9. Differentiation of Human Hair Follicle Stem Cells Into Endothelial Cells Induced by Vascular Endothelial and Basic Fibroblast Growth Factors Molecular Medicine Reports · 2013
    10. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    11. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    12. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    13. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    14. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    15. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    16. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    17. Androgens and Hair Growth Dermatologic Therapy · 2008
    18. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    19. Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox Seminars in Cell & Developmental Biology · 2007
    20. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    21. Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle Journal of Investigative Dermatology Symposium Proceedings · 2005
    22. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    23. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    24. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003
    25. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    26. Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing Journal of Burn Care & Rehabilitation · 2002
    27. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    28. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998

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