TLDR Human hair follicle stem cells can become endothelial cells with certain growth factors, useful for vascular treatments.
The study demonstrated that human hair follicle stem cells (hHFSCs) could be efficiently differentiated into endothelial cells (ECs) using vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). The differentiated cells expressed EC-specific markers and were capable of low-density lipoprotein uptake, indicating their functionality as ECs. This suggested that hHFSCs could be a novel and accessible cell source for vascular tissue engineering and potential treatments for ischemic vascular diseases.
65 citations
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November 2012 in “Tissue Engineering Part B-reviews” Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.
344 citations
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June 2006 in “American Journal Of Pathology” 268 citations
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December 2003 in “Experimental Dermatology” Hair follicle cells can become fat and bone cells.
5 citations
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October 2021 in “Frontiers in Cell and Developmental Biology” Fat tissue under the skin affects hair growth and aging; reducing its inflammation may help treat hair loss.
45 citations
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October 2014 in “Stem cell research & therapy” Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.
35 citations
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October 2013 in “Journal of Dermatological Science” VEGF165 influences hair follicle cell growth and movement through VEGFR-2 activation.
17 citations
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February 2018 in “Journal of Cosmetic and Laser Therapy” The QR 678 hair growth treatment was safe and effective for hair regrowth in men and women.
50 citations
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May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
