Amelioration of Androgenetic Alopecia by Algal Oligosaccharides Prepared by Deep-Sea Bacterium Biodegradation

September 2020 in “ Frontiers in Microbiology ”

Min Jin, Yu-Lei Chen, Xiongfei He, Yanping Hou, Zhuhua Chan, Runying Zeng

androgenetic alopecia algal oligosaccharides DHT anagen phase dermal papillae cells hair follicles AGA AOS

TLDR Algal oligosaccharides help prevent hair loss and promote hair growth.

The study investigated the potential of algal oligosaccharides (AOS) in preventing or treating androgenetic alopecia (AGA). AOS exhibited antagonistic effects against DHT-mediated cellular signaling and anagen phase shortening, which play key roles in AGA pathogenesis. AOS induced hair-growth-stimulating factors and suppressed hair-growth-inhibitory factors in dermal papillae cells, thus restoring the DHT-induced alteration of regulatory factors and prolonging the anagen phase of hair follicles in mice. The study suggests that AOS may have potential applications in the prevention and treatment of DHT-induced AGA.

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