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GlossaryHair Follicle Epithelial Stem Cells (HFSCs)

specialized cells that regenerate and produce new hair

Hair Follicle Epithelial Stem Cells are specialized cells located in the hair follicle that have the ability to regenerate and produce new hair. These cells play a crucial role in the growth cycle of hair, as they can differentiate into various cell types needed for hair formation and repair, making them essential for maintaining healthy hair and potentially treating conditions like alopecia.

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research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations, March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research In Vitro Hair Growth-Promoting Effect of Lgr5-Binding Octapeptide in Human Primary Hair Cells

October 2023 in “Journal of Cosmetic Dermatology”

A synthetic octapeptide may help promote hair growth and counteract hair loss.

research Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying

13 citations, May 2022 in “Cell discovery”

The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.

research Stem Cell Therapy in Androgenetic Alopecia: A Review of Dermatology Literature from 2012 to 2022

October 2024

Stem cell therapy shows promise for treating hair loss in androgenetic alopecia.

research A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

31 citations, August 2021 in “Stem Cell Research & Therapy”

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

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community TDM-105795 phase 2 results are in!

in Research/Science 28 upvotes 10 months ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.