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GlossaryTelomerase Reverse Transcriptase (hTERT)

enzyme that maintains telomere length, crucial for cell division

Telomerase Reverse Transcriptase (TERT) is an enzyme that helps maintain the length of telomeres, which are protective caps at the ends of chromosomes. By adding repetitive nucleotide sequences to the telomeres, TERT plays a crucial role in cellular aging and replication. This enzyme is particularly active in stem cells, germ cells, and cancer cells, allowing them to divide indefinitely.

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research The Use of Polyethylenimine–DNA to Topically Deliver hTERT to Promote Hair Growth

17 citations , May 2011 in “Gene Therapy”

Using polyethylenimine-DNA to deliver the hTERT gene can stimulate hair growth and may be useful in treating hair loss, but there could be potential cancer risks.

research Induction of Type 17 Collagen Decreases Ultraviolet B-Induced Cellular Senescence in Human hTert/KER-CT Keratinocytes

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.

research The Formation of Hair Follicle Induced by Immortalized Human Dermal Papilla Cell Line In Vivo

January 2011 in “The Chinese Journal of Dermatovenereology”

DPC-hTERT cells can create hair follicle-like structures.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

research Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture

28 citations , March 2010 in “Histochemistry and cell biology”

Skin cells can help create early hair-like structures in lab cultures.

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community So is sublingual topical minoxidil not as effective as oral?

in Minoxidil 8 upvotes 4 years ago

Topical liquid minoxidil may be safe to consume in small amounts, but it needs liver processing to become effective for hair growth. Therefore, oral pills might be more effective.

community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems

in Minoxidil 24 upvotes 4 years ago

Oral minoxidil may improve hair growth, reduce arterial stiffness, and prevent other health issues. Some users believe it is an effective treatment despite concerns about its effects on skin and blood.