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GlossaryTelomerase

enzyme that extends chromosome ends to prevent shortening

Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, known as telomeres, to prevent them from becoming too short during cell division. This process is crucial for maintaining the stability and integrity of genetic information, particularly in stem cells and cancer cells, which divide frequently.

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research Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells

414 citations, August 2005 in “Nature”

Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.

research Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research

12 citations, January 2021 in “Journal of Investigative Dermatology”

Hair follicle studies suggest that maintaining telomere length could help treat hair loss and graying, but it's uncertain if mouse results apply to humans.

research Perspectives in Dermatopathology: Telomeres and Telomerase in Aging and Cancer with Emphasis on Cutaneous Disease

11 citations, January 2000 in “Journal of Cutaneous Pathology”

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

research Immunolocalization of Telomerases in Human Hairs Identifies Proliferating Cells in the Bulb Matrix and Outer Root Sheath

March 2024 in “Tissue and cell/Tissue & cell”

Telomerase-positive cells are mainly in the bulb matrix and outer root sheath of hair follicles.

research Faculty Opinions Recommendation of Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells

October 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Activating telomerase can boost hair follicle stem cell growth and hair production.

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community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 76 upvotes 2 years ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

community PP405 Might Be the Closest We Have to a Upcoming Cure

in Technology 237 upvotes 3 weeks ago

PP405 is considered a promising potential cure for hair loss, with phase 2 trial results expected in February 2025. Hair cloning is also discussed as a potential ultimate solution, despite significant scientific challenges.

community Pyrilutamide just launched internationally, and all you're doing is hating

in Product 5 months ago

The post and conversation are about the high cost and skepticism surrounding pyrilutamide as a hair loss treatment, with comparisons to minoxidil, finasteride, and RU58841. The original poster defends pyrilutamide's effectiveness and criticizes others for dismissing it without proper understanding.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 1 year ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community M26 - 9 months after hair transplant! AMA

in Transplants 624 upvotes 5 years ago

A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.