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    Glossary Telomerase

    enzyme that extends chromosome ends to prevent shortening

    Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, known as telomeres, to prevent them from becoming too short during cell division. This process is crucial for maintaining the stability and integrity of genetic information, particularly in stem cells and cancer cells, which divide frequently.

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    Research 30 of 571

    1. Conditional telomerase induction causes proliferation of hair follicle stem cells Nature · 2005 · 414 citations
    2. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Aging Cell · 2016 · 30 citations
    3. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    4. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021 · 12 citations
    5. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations
    6. Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita Science Advances · 2025 · 3 citations
    7. Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath 2024
    8. Stem and cancer cells Wnt long telomeres Nature Cell Biology · 2012
    9. Faculty Opinions recommendation of Conditional telomerase induction causes proliferation of hair follicle stem cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2005
    10. The Telomerase Reverse Transcriptase (TERT) Gene Molecular Characterization in Sheep and the Association of Its Variation with Wool Traits Animals · 2026
    11. Dietary Selenium Deprivation Oppositely Impacts Longevity and Healthspan in Telomere Dysfunctional Mice ˜The œFASEB journal · 2017
    12. The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells edoc (University of Basel) · 2013
    13. Local Artemis dysfunction may be one molecular mechanism for androgenetic alopecia via telomere shortening Medical Hypotheses · 2012
    14. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length GeroScience · 2021 · 20 citations
    15. Anti-aging Effect and Regression of Wart by Increasing Normal Cell Telomere: The Efficacy of Far-infrared Oily Cream Acupuncture & Electro-Therapeutics Research · 2010
    16. Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study Frontiers in Immunology · 2023 · 4 citations
    17. Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells Cancer Science · 2008 · 145 citations
    18. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009 · 326 citations
    19. Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells Stem Cells and Development · 2006 · 151 citations
    20. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    21. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    22. Do Changes in Chromosomes Cause Aging? Cell · 1996 · 50 citations
    23. Dermal papilla cells induce keratinocyte tubulogenesis in culture Histochemistry and cell biology · 2010 · 28 citations
    24. Stem cells and aberrant signaling of molecular systems in skin aging Ageing Research Reviews · 2014 · 25 citations
    25. Fisetin Promotes Hair Growth by Augmenting TERT Expression Frontiers in Cell and Developmental Biology · 2020 · 22 citations
    26. Establishment and characterization of an immortalized human dermal papilla cell line BMB Reports · 2011 · 21 citations
    27. Normal and Aging Hair Biology and Structure ‘Aging and Hair' Current problems in dermatology · 2015 · 20 citations
    28. Novel in vitro culture condition improves the stemness of human dermal stem/progenitor cells Molecules and Cells · 2013 · 18 citations
    29. Cutaneous gene therapy Annals of Medicine · 2007 · 17 citations
    30. Establishment and characterization of five immortalized human scalp dermal papilla cell lines Biochemical and Biophysical Research Communications · 2018 · 16 citations