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GlossaryTelomeres

protective DNA caps at chromosome ends preventing genetic loss

Telomeres are protective caps located at the ends of chromosomes, composed of repetitive DNA sequences. They prevent the loss of important genetic information during cell division and play a crucial role in cellular aging and stability. Over time, as cells divide, telomeres shorten, which can eventually lead to cell death or malfunction, contributing to aging and diseases such as cancer.

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research Perspectives in Dermatopathology: Telomeres and Telomerase in Aging and Cancer with Emphasis on Cutaneous Disease

11 citations, January 2000 in “Journal of Cutaneous Pathology”

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

research Stem and Cancer Cells Wnt Long Telomeres

August 2012 in “Nature Cell Biology”

A pathway helps maintain long telomeres in both stem and cancer cells.

Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

4 citations, January 2023 in “Frontiers in Immunology”

Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.

research Skin Connective Tissue and Aging

77 citations, July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

research Long-Term Administration of Triterpenoids From Ganoderma Lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice

9 citations, May 2021 in “Frontiers in aging neuroscience”

Taking triterpenoids from Ganoderma lucidum over a long time can help slow down brain aging and improve overall health in mice.

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