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    Glossary Telomeres

    protective DNA caps at chromosome ends preventing genetic loss

    Telomeres are protective caps located at the ends of chromosomes, composed of repetitive DNA sequences. They prevent the loss of important genetic information during cell division and play a crucial role in cellular aging and stability. Over time, as cells divide, telomeres shorten, which can eventually lead to cell death or malfunction, contributing to aging and diseases such as cancer.

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    Research 10 of 618

    1. Conditional telomerase induction causes proliferation of hair follicle stem cells Nature · 2005 · 414 citations
    2. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Aging Cell · 2016 · 30 citations
    3. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    4. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021 · 12 citations
    5. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations
    6. Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita Science Advances · 2025 · 3 citations
    7. Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath 2024
    8. Dietary Selenium Deprivation Oppositely Impacts Longevity and Healthspan in Telomere Dysfunctional Mice ˜The œFASEB journal · 2017
    9. The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells edoc (University of Basel) · 2013
    10. Stem and cancer cells Wnt long telomeres Nature Cell Biology · 2012
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