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    Glossary Telomeres

    protective DNA caps at chromosome ends preventing genetic loss

    Telomeres are protective caps located at the ends of chromosomes, composed of repetitive DNA sequences. They prevent the loss of important genetic information during cell division and play a crucial role in cellular aging and stability. Over time, as cells divide, telomeres shorten, which can eventually lead to cell death or malfunction, contributing to aging and diseases such as cancer.

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    Research 30 of 618

    1. Conditional telomerase induction causes proliferation of hair follicle stem cells Nature · 2005 · 414 citations
    2. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Aging Cell · 2016 · 30 citations
    3. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    4. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021 · 12 citations
    5. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations
    6. Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita Science Advances · 2025 · 3 citations
    7. Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath 2024
    8. Dietary Selenium Deprivation Oppositely Impacts Longevity and Healthspan in Telomere Dysfunctional Mice ˜The œFASEB journal · 2017
    9. The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells edoc (University of Basel) · 2013
    10. Stem and cancer cells Wnt long telomeres Nature Cell Biology · 2012
    11. Faculty Opinions recommendation of Conditional telomerase induction causes proliferation of hair follicle stem cells. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2005
    12. Local Artemis dysfunction may be one molecular mechanism for androgenetic alopecia via telomere shortening Medical Hypotheses · 2012
    13. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length GeroScience · 2021 · 20 citations
    14. The Telomerase Reverse Transcriptase (TERT) Gene Molecular Characterization in Sheep and the Association of Its Variation with Wool Traits Animals · 2026
    15. Anti-aging Effect and Regression of Wart by Increasing Normal Cell Telomere: The Efficacy of Far-infrared Oily Cream Acupuncture & Electro-Therapeutics Research · 2010
    16. Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study Frontiers in Immunology · 2023 · 4 citations
    17. Targeting telomeric RNA quadruplexes with natural metabolites to prevent cancer In Silico Pharmacology · 2024 · 2 citations
    18. Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells Cancer Science · 2008 · 145 citations
    19. Skin connective tissue and ageing Best Practice & Research in Clinical Obstetrics & Gynaecology · 2013 · 77 citations
    20. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    21. Shared Phenotypes Among Segmental Progeroid Syndromes Suggest Underlying Pathways of Aging The Journals of Gerontology Series A · 2005 · 69 citations
    22. Do Changes in Chromosomes Cause Aging? Cell · 1996 · 50 citations
    23. Dermal papilla cells induce keratinocyte tubulogenesis in culture Histochemistry and cell biology · 2010 · 28 citations
    24. Stem cells and aberrant signaling of molecular systems in skin aging Ageing Research Reviews · 2014 · 25 citations
    25. Normal and Aging Hair Biology and Structure ‘Aging and Hair' Current problems in dermatology · 2015 · 20 citations
    26. Cutaneous gene therapy Annals of Medicine · 2007 · 17 citations
    27. Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice Frontiers in aging neuroscience · 2021 · 9 citations
    28. Montagna Symposium 2014—Skin Aging: Molecular Mechanisms and Tissue Consequences 2015 · 9 citations
    29. Adenine supplement delays senescence in cultured human follicle dermal papilla cells Experimental dermatology · 2015 · 6 citations
    30. Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells Scientific Reports · 2020 · 4 citations