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GlossaryTelomere Shortening

gradual reduction of protective chromosome ends during cell division

Telomere shortening refers to the gradual reduction in the length of telomeres, which are protective caps at the ends of chromosomes. Each time a cell divides, its telomeres become slightly shorter, eventually leading to cellular aging and dysfunction when they become critically short. This process is also known as telomere attrition and is a key factor in aging and age-related diseases.

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research Local Artemis Dysfunction May Be One Molecular Mechanism for Androgenetic Alopecia via Telomere Shortening

October 2012 in “Medical Hypotheses”

Artemis dysfunction might cause hair loss through telomere shortening.

research Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling

19 citations, September 2019 in “PLOS genetics”

Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.

research Replicative Stress, Stem Cells, and Aging

70 citations, March 2008 in “Mechanisms of Ageing and Development”

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

research Do Changes in Chromosomes Cause Aging?

50 citations, July 1996 in “Cell”

Chromosomal changes, including those in the WRN gene and rDNA, may significantly contribute to aging.

research Stem Cells and Aberrant Signaling of Molecular Systems in Skin Aging

25 citations, November 2014 in “Ageing Research Reviews”

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

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community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 1 year ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

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in Progress Pictures 76 upvotes 1 year ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

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in Transplants 624 upvotes 4 years ago

A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.

community Pyrilutamide just launched internationally, and all you're doing is hating

in Product 3 months ago

The post and conversation are about the high cost and skepticism surrounding pyrilutamide as a hair loss treatment, with comparisons to minoxidil, finasteride, and RU58841. The original poster defends pyrilutamide's effectiveness and criticizes others for dismissing it without proper understanding.