Do Changes in Chromosomes Cause Aging?

July 1996 in “ Cell ”

Leonard Guarente

chromosomes aging genetic factors epigenetic factors Werner's Syndrome WRN gene premature aging accumulated damage genetic programming model organisms Drosophila C. elegans yeast cellular-level processes oxidative damage telomere shortening loss of silencing DNA damage genes fruit flies roundworms baker's yeast cell damage chromosome changes

Studysummary This review discusses genetic and epigenetic mechanisms that may contribute to aging and presents models suggesting that chromosomal changes could play a key role in the aging process; it reports no new experimental findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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