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    Glossary Telomere Shortening

    gradual reduction of protective chromosome ends during cell division

    Telomere shortening refers to the gradual reduction in the length of telomeres, which are protective caps at the ends of chromosomes. Each time a cell divides, its telomeres become slightly shorter, eventually leading to cellular aging and dysfunction when they become critically short. This process is also known as telomere attrition and is a key factor in aging and age-related diseases.

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    Research 30 of 409

    1. Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita Science Advances · 2025 · 3 citations
    2. Local Artemis dysfunction may be one molecular mechanism for androgenetic alopecia via telomere shortening Medical Hypotheses · 2012
    3. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    4. Do Changes in Chromosomes Cause Aging? Cell · 1996 · 50 citations
    5. Stem cells and aberrant signaling of molecular systems in skin aging Ageing Research Reviews · 2014 · 25 citations
    6. Normal and Aging Hair Biology and Structure ‘Aging and Hair' Current problems in dermatology · 2015 · 20 citations
    7. Causality of Aging Hallmarks Aging and Disease · 2025 · 1 citations
    8. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    9. Le vieillissement de la peau et du follicule pileux : de la caractérisation clinique à l'étude fonctionnelle Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) · 2015 · 1 citations
    10. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    11. Loss of Repressor Activator Protein 1 Precipitates Cardiac Aging in Mice via p53/PPARα Signaling The FASEB Journal · 2020
    12. Lamins in development, tissue maintenance and stress EMBO reports · 2012 · 64 citations
    13. Quoi de neuf en recherche dermatologique ? Annales de Dermatologie et de Vénéréologie · 2011 · 2 citations
    14. Myotonic Dystrophy—A Progeroid Disease? Frontiers in Neurology · 2018 · 41 citations
    15. SOVEREIGN PROJECT RE-GENESIS: CONTINUOUS-WAVE PHONOPHORETIC QUANTUM-VOLUMETRIC REGENERATION SYSTEM (CQ-VRS) Zenodo (CERN European Organization for Nuclear Research) · 2026
    16. SOVEREIGN PROJECT RE-GENESIS: CONTINUOUS-WAVE PHONOPHORETIC QUANTUM-VOLUMETRIC REGENERATION SYSTEM (CQ-VRS) Zenodo (CERN European Organization for Nuclear Research) · 2026
    17. A Story About Hair Oncology Times · 2018
    18. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations
    19. Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Aging Cell · 2016 · 30 citations
    20. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021 · 12 citations
    21. Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study Frontiers in Immunology · 2023 · 4 citations
    22. New intranasal and injectable gene therapy for healthy life extension bioRxiv (Cold Spring Harbor Laboratory) · 2021
    23. Conditional telomerase induction causes proliferation of hair follicle stem cells Nature · 2005 · 414 citations
    24. Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice Frontiers in aging neuroscience · 2021 · 9 citations
    25. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    26. Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies Journal of Cellular and Molecular Medicine · 2009 · 36 citations
    27. Pathology of Mouse Models of Accelerated Aging Veterinary pathology · 2016 · 81 citations
    28. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    29. Establishment of keratinocyte cell lines from human hair follicles Scientific reports · 2018 · 16 citations
    30. Design and development of cosmeceutical cream for hyperpigmentation and anti-aging International Journal of Advanced Community Medicine · 2018 · 2 citations