Long-Term Administration of Triterpenoids From Ganoderma Lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice

The study investigated the long-term effects of triterpenoids from Ganoderma lucidum (TGL) on age-associated brain decline in mice, involving 100 normal aging mice and additional transgenic mice for Alzheimer's Disease (AD) models. TGL administration over 10 months improved various aging indicators, including smoother fur, better skin condition, fewer cataracts, and improved liver function. Key findings included reduced apoptosis, longer telomeres, and upregulated autophagy markers. Metabolomics analysis revealed significant differences in sphingolipid metabolites, suggesting TGL targets sphingolipid metabolism to exert its anti-aging effects. The results indicated potential therapeutic benefits for age-related neurodegenerative conditions.