Long-Term Administration of Triterpenoids From Ganoderma Lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice
May 2021
in “
Frontiers in aging neuroscience
”
New to Reishi? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that long-term use of triterpenoids from Ganoderma lucidum may improve brain function and alleviate aging-related issues in normal and Alzheimer's mouse models. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the long-term effects of triterpenoids from Ganoderma lucidum (TGL) on age-associated brain decline in mice, involving 100 normal aging mice and additional transgenic mice for Alzheimer's Disease (AD) models. TGL administration over 10 months improved various aging indicators, including smoother fur, better skin condition, fewer cataracts, and improved liver function. Key findings included reduced apoptosis, longer telomeres, and upregulated autophagy markers. Metabolomics analysis revealed significant differences in sphingolipid metabolites, suggesting TGL targets sphingolipid metabolism to exert its anti-aging effects. The results indicated potential therapeutic benefits for age-related neurodegenerative conditions.
