LncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via Trans-Regulatory Actions

The study investigates the role of lncRNA2919 in rabbit dermal papilla cells (DPCs) and its impact on hair follicle (HF) cyclic regeneration. The researchers found that lncRNA2919 suppresses DPC proliferation and promotes apoptosis by downregulating HF growth-related genes and proteins such as LEF1, CCND1, and WNT2. It achieves this by recruiting the transcription factor STAT1 to regulate the expression of KRTAP11-1. The findings suggest that lncRNA2919 plays a significant role in HF cyclic regeneration through the lncRNA2919–STAT1–KRTAP11-1 axis and could serve as a potential therapeutic target for animal wool production and human hair-related diseases.