Building Models for Keratin Disorders

    May 2012 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Maranke I. Koster
    TLDR Krt16-deficient mice help understand skin disorders like PC and FNEPPK.
    Lessard and Coulombe generated keratin 16 (Krt16)-deficient mice to create a model replicating palmoplantar keratoderma, a hallmark of pachyonychia congenita (PC) and focal non-epidermolytic palmoplantar keratoderma (FNEPPK). This model aimed to provide novel insights into the molecular mechanisms behind palmoplantar lesions in PC and FNEPPK patients.
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