Whole-Transcriptome Analysis Reveals the Profiles and Roles of Coding and Non-Coding RNAs During Hair Follicle Cycling in Rex Rabbits

    January 2025 in “ BMC Genomics ”
    Jie Wu, Jixian Zhai, Haijiang Jia, Ifeanyi Solomon Ahamba, Xianggui Dong, Ren Zhanjun
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    TLDR Key genes and RNA networks regulate hair growth and follicle density in Rex rabbits.
    This study on Rex rabbits used whole-transcriptome sequencing to analyze the roles of coding and non-coding RNAs during hair follicle cycling, involving 40 rabbits. Researchers identified thousands of mRNAs, lncRNAs, circRNAs, and miRNAs, with significant expression differences across hair follicle stages (anagen, catagen, telogen). Key pathways such as PI3K-Akt, Wnt, and MAPK were crucial for hair follicle regulation. The study constructed lncRNA/circRNA-miRNA-mRNA networks, identifying genes like S100A3, LGR5, SHH, and GLI2 as significant for hair growth and follicle density. These findings enhance understanding of molecular mechanisms in hair growth, offering potential targets for improving fur traits and understanding hair diseases in mammals.
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