MiR-22 Promotes Stem Cell Traits Via Activating Wnt/β-Catenin Signaling In Cutaneous Squamous Cell Carcinoma

August 2021 in “ Oncogene ”

Shukai Yuan, Peitao Zhang, Liqi Wen, Shikai Jia, Yufan Wu, Zhenlei Zhang, Lizhao Guan, Zhengquan Yu, Li Zhao

miR-22 Wnt/β-catenin signaling cutaneous squamous cell carcinoma citrullinase PAD2 DKK1 FosB-DDK1 transcriptional axis β-catenin

TLDR miR-22 helps skin cancer grow and spread by activating specific cell signals.

The study reported that miR-22 played a significant role in promoting tumor initiation, progression, and metastasis in cutaneous squamous cell carcinoma by maintaining Wnt/β-catenin signaling and cancer stem cell function. miR-22 facilitated β-catenin stabilization by repressing citrullinase PAD2 and relieved DKK1-mediated repression of Wnt/β-catenin signaling by targeting a FosB-DDK1 transcriptional axis. In miR-22 knockout mice, there was a noted reduction in Wnt/β-catenin activity, indicating the importance of miR-22 in these oncogenic processes.

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MiR-22 Promotes Stem Cell Traits Via Activating Wnt/β-Catenin Signaling In Cutaneous Squamous Cell Carcinoma

Research cited in this study

research A Slow-Cycling LGR5 Tumor Population Mediates Basal Cell Carcinoma Relapse After Therapy

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research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

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