Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats
August 2022
in “
Frontiers in Veterinary Science
”
circRNAs miRNAs Wnt pathway TGF-β pathway Notch pathway NF-Kappa B pathway ceRNA regulatory network circRNA5712 miR-27b-3p DLL4 secondary hair follicles hair follicle development circular RNAs microRNAs Wnt signaling TGF-beta signaling Notch signaling NF-Kappa B signaling competitive endogenous RNA network hair follicles
TLDR The research found key RNA networks that may control hair growth in cashmere goats.
The research investigated the role of circular RNAs (circRNAs) in the development of secondary hair follicles in cashmere goats. It identified 113 circRNAs related to this development, which were predicted to target 117 miRNAs, forming 194 circRNA-miRNA regulatory networks. Additionally, 21 key miRNAs were identified, predicted to target 110 genes enriched in Wnt, TGF-β, Notch, and NF-Kappa B pathways, constructing 280 miRNA-mRNA regulatory networks. The study also constructed a ceRNA regulatory network consisting of 13 circRNAs, 21 miRNAs, and 110 mRNAs. Four key circRNAs were expressed in the fetal skin of cashmere goats at different stages. Particularly, circRNA5712 was found to bind to miR-27b-3p and DLL4, suggesting it may regulate the development of secondary hair follicles. The findings provide a foundation for understanding the molecular mechanisms of hair follicle development in cashmere goats.
