TLDR A circular RNA helps cashmere goat hair cells become hair follicles by blocking a molecule to boost a gene important for hair growth.
The study investigated the role of a newly identified circular RNA, circRNA-0100, in the development of secondary hair follicles (SHF) in cashmere goats. The researchers found that circRNA-0100 was expressed at higher levels during the anagen (growth) phase of SHF compared to the telogen (resting) phase. They used overexpression and siRNA interference assays to demonstrate that circRNA-0100 promotes the differentiation of SHF stem cells (SHF-SCs) into hair follicle lineage, as evidenced by changes in the transcriptional levels of six indicator genes. The study also showed that circRNA-0100 acts as a molecular sponge for miR-153-3p, which in turn positively regulates the expression of the KLF5 gene, a process important for hair follicle differentiation. These findings suggest that circRNA-0100 may enhance the differentiation of SHF-SCs into hair lineage by sequestering miR-153-3p to increase KLF5 expression, providing insight into the molecular mechanisms regulating hair follicle development in cashmere goats.
16 citations,
September 2020 in “Animals” circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.
71 citations,
January 2019 in “International journal of biological sciences” Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.
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November 2017 in “Molecular Medicine Reports” PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.
42 citations,
September 2015 in “Gene” FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.
149 citations,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.
173 citations,
January 2014 in “Nature Cell Biology” Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
10 citations,
January 2014 in “Genetics and Molecular Research” Liaoning Cashmere goat hair follicles show synchronized growth patterns with lowest activity in May.
2 citations,
February 2022 in “Genomics” Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.
8 citations,
July 2020 in “BMC genomics” The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
14 citations,
January 2015 in “Genetics and molecular research” The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
61 citations,
April 2013 in “PloS one” The study found key genes and pathways involved in cashmere goat hair growth stages.
22 citations,
July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture” Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.
