CircRNA-1926 Promotes Differentiation of Goat SHF Stem Cells into Hair Follicle Lineage by miR-148a/b-3p/CDK19 Axis
September 2020
in “
Animals
”
TLDR circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.
The study demonstrated that circRNA-1926 promoted the differentiation of secondary hair follicle (SHF) stem cells into hair follicle lineages in cashmere goats by acting as a molecular sponge for miR-148a/b-3p, thereby upregulating CDK19 expression. This regulatory mechanism facilitated the differentiation process, suggesting that circRNA-1926 could be a potential target for enhancing hair follicle regeneration and treating hair loss conditions. The study involved nine adult female Liaoning cashmere goats and provided new insights into the molecular mechanisms underlying hair follicle regeneration and cashmere growth.
