Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

    March 2013 in “ Journal of Applied Biomedicine ”
    Yi Zhang, Jin Yü, Chunying Shi … Yang Tian
    Studysummary This study found that β-catenin is essential for hair follicle stem cell proliferation and may regulate this process through the PI3K/Akt pathway, suggesting its potential as a therapeutic target.
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    Research cited in this study 8

    1. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    2. Embryonic Hair Follicle Fate Change by Augmented Beta-Catenin Through Shh and Bmp Signaling Development · 2009
    3. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    5. Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties Colloids and Surfaces B: Biointerfaces · 2006
    6. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    7. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    8. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000