Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

March 2013 in “ Journal of Applied Biomedicine ”

Yi Zhang, Jin Yü, Chunying Shi, Yun Wang, Jin Yang, Yang Tian

β-catenin hair follicle stem cells PI3K/Akt pathway nuclear translocation cyclin D1 p21 keratinocytes

Studysummary This study found that β-catenin is essential for hair follicle stem cell proliferation and may regulate this process through the PI3K/Akt pathway, suggesting its potential as a therapeutic target. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated that β-catenin played a crucial role in the proliferation of hair follicle stem cells (HFSCs) by activating the PI3K/Akt pathway. The research showed that β-catenin activation was linked to HFSCs proliferation through the nuclear translocation of stabilized β-catenin and the activation of cell cycle genes such as cyclin D1 and p21. This indicated that β-catenin was essential for HFSCs proliferation and could serve as a potential therapeutic target for enhancing the production of keratinocytes from HFSCs.

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Research cited in this study

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This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.

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This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.