Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

The study demonstrated that β-catenin played a crucial role in the proliferation of hair follicle stem cells (HFSCs) by activating the PI3K/Akt pathway. The research showed that β-catenin activation was linked to HFSCs proliferation through the nuclear translocation of stabilized β-catenin and the activation of cell cycle genes such as cyclin D1 and p21. This indicated that β-catenin was essential for HFSCs proliferation and could serve as a potential therapeutic target for enhancing the production of keratinocytes from HFSCs.