Embryonic Hair Follicle Fate Change by Augmented Beta-Catenin Through Shh and Bmp Signaling

The study explored the impact of augmented β-catenin on embryonic hair follicle fate, focusing on its interaction with Shh and Bmp signaling pathways. Using mutant mice with active β-catenin in keratinocytes, researchers observed changes in hair follicle fate, evidenced by scaly skin and altered epidermal characteristics. The study demonstrated that β-catenin signaling, through Shh and Bmp pathways, was crucial for hair follicle fate change. Mutations in these pathways suppressed the hair follicle fate switch, highlighting their regulatory role. The findings suggested that Shh was essential for hair follicle fate expansion, while Bmp acted as an inhibitor, indicating a reaction-diffusion mechanism in hair follicle patterning.