Faculty Opinions Recommendation of Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways

Sharov et al. investigated the role of the bone morphogenetic protein (BMP) antagonist Noggin in skin tumorigenesis, using a mouse model. They found that Noggin promotes skin cancer development by stimulating the Wnt and sonic hedgehog (Shh) signaling pathways. The study demonstrated that BMP signaling acts as a tumor suppressor by inhibiting these pathways, highlighting its importance in maintaining epithelial homeostasis and preventing malignant growth. This research underscored the complexity of signaling networks in tissue regulation and the potential of targeting these pathways for cancer therapy.