Faculty Opinions Recommendation of Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways

    December 2009 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Asma Nusrat, Stefan Koch
    TLDR Noggin promotes skin tumors by activating Wnt and Shh pathways.
    Sharov et al. investigated the role of the bone morphogenetic protein (BMP) antagonist Noggin in skin tumorigenesis, using a mouse model. They found that Noggin promotes skin cancer development by stimulating the Wnt and sonic hedgehog (Shh) signaling pathways. The study demonstrated that BMP signaling acts as a tumor suppressor by inhibiting these pathways, highlighting its importance in maintaining epithelial homeostasis and preventing malignant growth. This research underscored the complexity of signaling networks in tissue regulation and the potential of targeting these pathways for cancer therapy.
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