Effects of Oleanolic Acid on Hair Growth in Mouse Dorsal Skin Mediated via Regulation of Inflammatory Cytokines

April 2023 in “ Journal of Applied Biomedicine ”

Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Xiaomin Zheng, Siyang Zhu, Baoshan Rong, Yong Ai, Lanyue Zhang, Tinggang He

TLDR Oleanolic acid improved hair growth in mice by affecting hair growth pathways and reducing inflammation.

The research studied the impact of oleanolic acid (OA), a compound found in over 200 plant species, on hair growth in mice with testosterone-induced androgenetic alopecia. The mice treated with 1% or 0.5% OA exhibited significantly improved hair growth, increased vascular endothelial growth factor/glyceraldehyde-3-phosphate dehydrogenase ratio, and elevated levels of fibroblast growth factor receptor and insulin-like growth factor 1. The study also discovered high expression of β-catenin, a crucial Wnt signalling transducer, in the OA-treated groups. The findings suggest that OA could enhance hair growth by stimulating hair matrix cell proliferation via the Wnt/β-catenin pathway and reducing the levels of tumour necrosis factor-alpha, transforming growth factor-beta 1, dihydrotestosterone, and 5α-reductase.

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