Effects of Oleanolic Acid on Hair Growth in Mouse Dorsal Skin Mediated via Regulation of Inflammatory Cytokines

    March 2023 in “ Journal of Applied Biomedicine
    Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Xiaomin Zheng, Siyang Zhu, Baoshan Rong, Yong Ai, Lanyue Zhang, Tinggang He
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    TLDR Oleanolic acid improved hair growth in mice by affecting hair growth pathways and reducing inflammation.
    The research studied the impact of oleanolic acid (OA), a compound found in over 200 plant species, on hair growth in mice with testosterone-induced androgenetic alopecia. The mice treated with 1% or 0.5% OA exhibited significantly improved hair growth, increased vascular endothelial growth factor/glyceraldehyde-3-phosphate dehydrogenase ratio, and elevated levels of fibroblast growth factor receptor and insulin-like growth factor 1. The study also discovered high expression of β-catenin, a crucial Wnt signalling transducer, in the OA-treated groups. The findings suggest that OA could enhance hair growth by stimulating hair matrix cell proliferation via the Wnt/β-catenin pathway and reducing the levels of tumour necrosis factor-alpha, transforming growth factor-beta 1, dihydrotestosterone, and 5α-reductase.
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