Loss of Memo, a Novel FGFR Regulator, Results in Reduced Lifespan

The study investigated the role of Memo, a 33-kDa protein, in fibroblast growth factor receptor (FGFR) signaling. Researchers used mouse embryonic fibroblasts and Memo conditional-knockout mice to explore its function. The absence of Memo was linked to reduced lifespan, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, and loss of spermatozoa. Additionally, Memo-knockout mice exhibited elevated levels of active vitamin D and calcium. The findings suggested that Memo was a novel regulator of FGFR signaling, influencing vitamin D production and calcium homeostasis.