Loss of Memo, a Novel FGFR Regulator, Results in Reduced Lifespan
September 2013
in “
The FASEB Journal
”
New to Vitamin D? There is a guide in the encyclopedia. Read the guide → Studysummary This study reports that the loss of the protein Memo in mice leads to a reduced lifespan and suggests that Memo is a key regulator of FGFR signaling and vitamin D production.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the role of Memo, a 33-kDa protein, in fibroblast growth factor receptor (FGFR) signaling. Researchers used mouse embryonic fibroblasts and Memo conditional-knockout mice to explore its function. The absence of Memo was linked to reduced lifespan, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, and loss of spermatozoa. Additionally, Memo-knockout mice exhibited elevated levels of active vitamin D and calcium. The findings suggested that Memo was a novel regulator of FGFR signaling, influencing vitamin D production and calcium homeostasis.
