Loss of Memo, a Novel FGFR Regulator, Results in Reduced Lifespan

The study investigated the role of Memo, a 33-kDa protein involved in cell motility, particularly in relation to FGFR signaling. Using mouse embryonic fibroblasts and Memo conditional-knockout mice, researchers found that Memo was crucial for optimal FGFR signaling. Memo-knockout mice exhibited a reduced lifespan, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, and loss of spermatozoa. Additionally, these mice had elevated levels of active vitamin D and calcium. The findings suggested that Memo was a novel regulator of FGFR signaling, influencing 1,25(OH)2D production and calcium homeostasis.