Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis evaluated the efficacy and tolerability of different concentrations of intralesional triamcinolone acetonide for treating focal alopecia areata. Seven studies with 543 participants were included. Hair regrowth rates were 62.3% for concentrations less than 5 mg/mL, 80.9% for 5 mg/mL, and 76.4% for 10 mg/mL. Skin atrophy occurred in 3.33% of subjects treated with 5 mg/mL and 20% with 10 mg/mL. The analysis suggested that 5 mg/mL offered the best risk-benefit ratio, but further randomized studies were recommended to determine the lowest effective concentration.