Screening of MicroRNA and mRNA Related to Secondary Hair Follicle Morphogenesis and Development and Functional Analysis in Cashmere Goats

April 2022 in “ Functional & Integrative Genomics ”

Fangzheng Shang, Yu Wang, Rong Ma, Youjun Rong, Min Wang, Zhihong Wu, Erhan Hai, Jianfeng Pan, Lili Liang, Zhiying Wang, Ruijun Wang, Rui Su, Zhihong Liu, Yanhong Zhao, Zhixin Wang, Jinquan Li, Yanjun Zhang

microRNA mRNA secondary hair follicles hair follicle development Notch signaling pathway TGF-β signaling pathway miR-145-5p DLL4 miR-193b-3p TGF-β1 chi-miR-30e-5p miRNA transforming growth factor beta Notch pathway

TLDR Key molecular interactions were identified that help understand hair follicle development in cashmere goats.

This study focused on the development of secondary hair follicles in cashmere goats by analyzing microRNA (miRNA) and mRNA expression profiles in fetal skin at different gestational ages. Researchers constructed and sequenced small RNA and mRNA libraries, identifying 66 miRNAs and 664 mRNAs related to hair follicle development. Key miRNA-mRNA interactions were found to be enriched in the Notch and TGF-β signaling pathways. Specific regulatory networks, such as miR-145-5p-DLL4 and miR-193b-3p-TGF-β1, were identified, with a dual-luciferase reporter assay confirming a targeted relationship between chi-miR-30e-5p and DLL4. These findings provided insights into the molecular mechanisms of hair follicle development in cashmere goats.

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Screening of MicroRNA and mRNA Related to Secondary Hair Follicle Morphogenesis and Development and Functional Analysis in Cashmere Goats

Research cited in this study

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