TLDR Key molecular interactions were identified that help understand hair follicle development in cashmere goats.
This study focused on the development of secondary hair follicles in cashmere goats by analyzing microRNA (miRNA) and mRNA expression profiles in fetal skin at different gestational ages. Researchers constructed and sequenced small RNA and mRNA libraries, identifying 66 miRNAs and 664 mRNAs related to hair follicle development. Key miRNA-mRNA interactions were found to be enriched in the Notch and TGF-β signaling pathways. Specific regulatory networks, such as miR-145-5p-DLL4 and miR-193b-3p-TGF-β1, were identified, with a dual-luciferase reporter assay confirming a targeted relationship between chi-miR-30e-5p and DLL4. These findings provided insights into the molecular mechanisms of hair follicle development in cashmere goats.
13 citations,
June 2020 in “BMC genomics” A specific microRNA, chi-miR-30b-5p, slows down the growth of hair-related cells by affecting the CaMKIIδ gene in cashmere goats.
137 citations,
September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
479 citations,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
2 citations,
February 2022 in “Genomics” Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.
8 citations,
July 2020 in “BMC genomics” The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
14 citations,
January 2015 in “Genetics and molecular research” The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
61 citations,
April 2013 in “PloS one” The study found key genes and pathways involved in cashmere goat hair growth stages.
22 citations,
July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture” Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.
