Genome-Wide Detection and Sequence Conservation Analysis of Long Non-Coding RNA During Hair Follicle Cycle of Yak

    October 2020 in “ BMC Genomics ”
    Xiaolan Zhang, Qi Bao, Congjun Jia, Chen Li, Yongfang Chang, Xiaoyun Wu, Chunnian Liang, Pengjia Bao, Ping Yan
    TLDR Long non-coding RNAs play a key role in yak hair growth cycles.
    The study investigated the role of long non-coding RNAs (lncRNAs) in the hair follicle cycle of yaks, identifying 2,884 lncRNAs across five phases. Differential expression analysis revealed significant changes in lncRNA expression between specific phases, with 198, 280, and 340 differentially expressed lncRNAs identified in the Oct.-vs-Jan., Jan.-vs-Mar., and Mar.-vs-Oct. comparisons, respectively. Functional analysis highlighted critical pathways like Wnt and VEGF signaling involved in hair follicle development. Comparative analysis with cashmere goats identified 24 differentially expressed lncRNAs with varying sequence conservation, providing insights into lncRNA functionality and mechanisms in hair follicle cycles.
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