Genome-Wide Detection and Sequence Conservation Analysis of Long Non-Coding RNA During Hair Follicle Cycle of Yak

    October 2020 in “ BMC Genomics ”
    Xiaolan Zhang, Qi Bao, Congjun Jia, Chen Li, Yongfang Chang, Xiaoyun Wu, Chunnian Liang, Pengjia Bao, Ping Yan
    TLDR Long non-coding RNAs play a key role in yak hair growth cycles.
    The study investigated long non-coding RNAs (lncRNAs) during the hair follicle cycle of yaks, identifying 2,884 lncRNAs across five phases, with 70.1% being novel. Differential expression analysis revealed 198, 280, and 340 differentially expressed lncRNAs (DELs) in three phase comparisons, linked to critical pathways like Wnt and VEGF signaling. Comparative analysis with cashmere goats identified 24 DELs with sequence conservation, suggesting potential key roles in hair follicle cycling. The research provided insights into the molecular mechanisms of hair growth in yaks, highlighting the importance of conserved lncRNA elements in hair follicle development and their evolutionary relationships with other species.
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