Screened of Long Non-Coding RNA Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep

January 2025 in “ BMC Genomics ”

Zhaohua He, Fangfang Zhao, Hongxian Sun, Jiang Hu, Jiqing Wang, Xiu Liu, Mingna Li, Hao Zhiyun, Zhidong Zhao, Bingang Shi, Feiyan Liu, Shaobin Li

long non-coding RNAs lncRNAs hair follicle development FOXN1 LIPK KRTAP5.4

TLDR Long non-coding RNAs help regulate wool fineness in Gansu alpine fine-wool sheep.

This study explores the role of long non-coding RNAs (lncRNAs) in the development and fineness of wool in Gansu alpine fine-wool sheep. By analyzing wool samples from 73 sheep, researchers identified 164 differentially expressed lncRNAs and 146 potential target genes, including FOXN1, LIPK, and KRTAP5.4, which are linked to hair follicle development. The study found that lncRNAs have lower expression levels and protein-coding potential compared to mRNAs, and they play a regulatory role in wool fineness, with finer wool fibers showing more regular scale distribution. These findings enhance the understanding of genetic factors affecting wool quality, offering potential applications in the textile industry.

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