Melatonin's Role in Hair Follicle Growth and Development: A Cashmere Goat Perspective

    Zibin Zheng, Zhenyu Su, Wei Zhang
    TLDR Melatonin promotes hair growth and quality by enhancing hair follicle development and reducing stress.
    This review examines melatonin's role in hair follicle growth and development in cashmere goats, emphasizing its regulatory effects on hair cycles and potential therapeutic applications for human alopecia. Melatonin, produced in the pineal gland, skin, and gut, enhances antioxidant capacity and modulates gene expression through pathways like Wnt and BMP, promoting hair follicle proliferation and extending cashmere growth periods. The study highlights melatonin's interaction with non-coding RNAs and the gut–skin axis, suggesting its integral role in hair growth regulation. Findings indicate that melatonin administration can improve cashmere yield and quality by influencing hair follicle characteristics and reducing oxidative stress.
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