Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

    February 2023 in “ International Journal of Molecular Sciences ”
    Xiaogao Diao, Chunhui Duan, Lingyun Yao, Jiaxin Qin, Liwen He, Wei Zhang
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    TLDR Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.
    The study, involving 15 goats in each of the 6 age groups (2, 3, 4, 5, 6, 7 years) for both the melatonin-treated and untreated control groups, found that melatonin (MT) improved the quality and yield of cashmere fibers in adult cashmere goats, particularly in those over 5 years old. This was achieved by increasing the number of secondary hair follicles, reducing oxidative stress, and regulating the Keap1-Nrf2 pathway. MT also reduced the expression of the inflammatory transcription factors NFκB and AP-1 and lowered levels of the SASP cytokines, which delayed skin aging and improved the microenvironment of secondary hair follicles.
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