Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

February 2023 in “ International Journal of Molecular Sciences ”

Xiaogao Diao, Chunhui Duan, Lingyun Yao, Jiaxin Qin, Liwen He, Wei Zhang

melatonin Keap1-Nrf2 signaling pathway NFκB AP-1 secondary hair follicles oxidative stress SASP cytokines skin aging microenvironment of hair follicles MT Keap1-Nrf2 NF-kappa B secondary follicles SASP hair follicle environment

Studysummary This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.

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research Effect of the FA2H Gene on Cashmere Fineness of Jiangnan Cashmere Goats Based on Transcriptome Sequencing

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research Identification of Genes Related to Hair Follicle Cycle Development in Inner Mongolia Cashmere Goat by WGCNA

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In this study, researchers identified ten key genes involved in the periodic development of hair follicles in cashmere goats, highlighting the importance of the Wnt signaling pathway and cell cycle in this process.

research Identification of the Key Genes Associated with Different Hair Types in the Inner Mongolia Cashmere Goat

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This study found that certain genes were significantly associated with hair length in Inner Mongolia cashmere goats, potentially serving as molecular markers for different hair types.

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

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This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.

research Protective Role of Melatonin and Its Metabolites in Skin Aging

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This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.

research Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

11 citations , June 2021 in “Frontiers in Cell and Developmental Biology”

This study found that melatonin may enhance goat cashmere growth by activating Wnt signaling and regulating stem cell pluripotency through mechanisms involving NOGGIN and BMP4 pathways.

research Inhibition of Prolactin Promotes Secondary Skin Follicle Activation in Cashmere Goats

7 citations , March 2021 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

In this study, bromocriptine's inhibition of prolactin promoted secondary follicle development during anagen in cashmere goats, likely via changes in specific gene expressions, despite not affecting fiber characteristics or primary follicle activity.

Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

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This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.

Effects of Melatonin Administration to Cashmere Goats on Cashmere Production and Hair Follicle Characteristics in Two Consecutive Cashmere Growth Cycles

research Effects of Melatonin Administration to Cashmere Goats on Cashmere Production and Hair Follicle Characteristics in Two Consecutive Cashmere Growth Cycles

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This study found that melatonin treatment improved cashmere production for one cycle in cashmere goats, enhancing fiber quality and follicle activity, but had no effects in the subsequent cycle.

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research Effect of Melatonin Administration to Lactating Cashmere Goats on Milk Production of Dams and Hair Follicle Development in Their Offspring

7 citations , November 2019 in “Animal”

This study found that melatonin treatment in adult cashmere goats increased cashmere yield and improved fibre quality without negatively affecting the hair follicle development or cashmere production in their offspring.

research Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Hair Follicle Cycling in Cashmere Goats

1 citations , August 2019 in “Research Square (Research Square)”

In this study, researchers found that the cashmere hair growth cycle is divided into three periods and key genes like KAP and KRTAP are positively correlated with these cycles in cashmere goats.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

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This study explored hair follicle gene expression in Inner Mongolia Cashmere goats and identified potential regulators of the transition between growth phases, including IL17RB and ZNF genes.

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research Effects of Photoperiod on Nutrient Digestibility, Hair Follicle Activity, and Cashmere Quality in Inner Mongolia White Cashmere Goats

11 citations , August 2018 in “Asian-Australasian journal of animal sciences”

This study found that a short daily photoperiod increased crude protein digestibility, secondary hair follicle activity, and cashmere quality in Inner Mongolia white cashmere goats without harming fiber characteristics.

Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

research Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

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