Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia

January 2013 in “ BioMed Research International ”

Piérard-Franchimont C, G. Loussouarn, S. Panhard, Didier Saint Léger, Myriam Mellul, Gérald Pierard

alopecia solar elastosis dermal cellularity dermal dendrocytes microvasculature epidermal proliferation versican+ stromal cells lymphatic vessels lysozyme deposits stress-induced premature senescence

Studysummary This study observed that both Factor XIIIa+ dermal dendrocytes and microvasculature size decreased with scalp aging and that alopecia changes resembled stress-induced premature senescence. Our plain-language summary of this paper — not a Tressless recommendation.

The study conducted on 650 Caucasian volunteers (300 women and 350 men) over 7 years examined the effects of age, gender, and alopecia on the interfollicular scalp. It found significant gender differences in young adults without alopecia, with men showing more solar elastosis, dermal cellularity, and dermal dendrocytes, while women had a more developed microvasculature. Ageing led to increased solar elastosis and decreased epidermal proliferation and dermal cellularity in both genders. Alopecia in young adults was linked to an increase in versican+ stromal cells and lymphatic vessels in men, and increased lysozyme deposits in women. The study concluded that alopecia may mimic stress-induced premature senescence and highlighted a strong gender effect on the scalp in young adults.

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