Androgenic Alopecia and Stress-Induced Premature Senescence by Cumulative Ultraviolet Light Exposure

January 2002 in “ Exogenous Dermatology ”

Claudine Franchimont, I. Uhoda, Didier Saint Léger, Gérald Pierard

androgenic alopecia AGA ultraviolet radiation UVR solar elastosis scalp dermis hair thinning hair diameter follicular stem cells sun protection anti-inflammatory measures pattern baldness sun damage skin aging hair loss stem cells sunblock anti-inflammatory treatments

TLDR Chronic exposure to sunlight may worsen male pattern baldness and protecting the scalp from the sun could slow it down.

The study involved 190 Caucasian men, with 140 having moderate pattern III androgenic alopecia (AGA) and 50 without alopecia, aged between 19 to 67 years, to investigate the relationship between AGA severity and chronic ultraviolet radiation (UVR) exposure, as indicated by solar elastosis in the scalp dermis. Results showed that men with AGA had a significantly thicker scalp dermis due to more severe solar elastosis. Signs of solar elastosis were present before hair thinning, and a negative exponential correlation was found between hair diameter and solar elastosis thickness over 0.2 mm. The study concluded that chronic UVR exposure may exacerbate AGA progression through stress-induced premature senescence of follicular stem cells, suggesting that sun protection and anti-inflammatory measures could slow AGA progression.

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