Developmental Mapping of Hair Follicles in the Embryonic Stages of Cashmere Goats Using Proteomic and Metabolomic Construction

    September 2023 in “ Animals ”
    Yuan Gao, Lei Duo, Xiaoshu Zhe, Hao Lu, Wenjing Song, Lei Gao, Jun Cai, Dongjun Liu
    TLDR Hair follicle development in cashmere goats involves dynamic changes in proteins and metabolites, with key roles for oxytocin, MAPK, and Ca2+ pathways.
    This study mapped hair follicle (HF) development in embryonic cashmere goats using proteomic and metabolomic analyses, identifying 1,784 differentially expressed proteins (DEPs) and 454 differentially expressed metabolites (DEMs) across stages E75 to E125. Key findings include the significant role of the oxytocin signaling pathway, which activates the MAPK and Ca2+ pathways, influencing HF development. The study also highlighted the importance of the neuroactive ligand–receptor interaction pathway and various metabolic pathways, such as nucleotide and cholesterol metabolism. These insights provide a comprehensive understanding of the molecular mechanisms driving HF development in cashmere goats, potentially informing breeding and genetic engineering strategies to improve cashmere quality.
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