Proteomic Analysis of Fetal Skin by iTRAQ Reveals Molecular Signals Underlying Inner Mongolia Cashmere Goat Hair Follicle Initiation

February 2023 in “ All Life ”

Xun Hu, Rugang Tian, Gaofeng Wang, Meng Zhao, Yanjun Zhang, Jinquan Li

iTRAQ keratins ECM-receptor interaction PI3K-Akt MAPK TGF-beta WNT hair follicle initiation hair follicle development keratin extracellular matrix-receptor interaction phosphoinositide 3-kinase-Akt mitogen-activated protein kinase transforming growth factor-beta Wnt signaling pathway

Studysummary This study identified proteins involved in hair follicle formation in cashmere goat embryos, highlighting potential signaling factors that may drive hair follicle initiation and cashmere growth.

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The study used iTRAQ technology to analyze protein expression in the skin of Inner Mongolia Cashmere goat embryos at 45, 55, and 65 days, identifying 1172 proteins with 188 differentially expressed. Key proteins such as various keratins and others involved in signaling pathways like ECM–receptor interaction, PI3K-Akt, MAPK, TGF-beta, and WNT were found to play crucial roles in hair follicle initiation and development. These findings provide insights into the molecular mechanisms of cashmere growth, which could improve cashmere quality through selective breeding.

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