Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing

    January 2018 in “ International Journal of Biological Sciences ”
    Fei Hao, Wei Yan, Xiaocong Li … Dongjun Liu
    Studysummary This study demonstrates the use of the CRISPR-Cas9 system to successfully edit the EDAR gene in Cashmere goats, resulting in goats with distinct hair follicle characteristics.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ijbs.com →
    Discuss this study in the Community →

    Research cited in this study 7

    1. Tβ4-Overexpression Based on the PiggyBac Transposon System in Cashmere Goats Alters Hair Fiber Characteristics Transgenic research · 2016
    2. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016
    3. Discovery of Differentially Expressed Genes in Cashmere Goat Hair Follicles by RNA Sequencing Genetics and Molecular Research · 2016
    4. The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015
    5. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    6. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    7. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002