Discovery of Differentially Expressed Genes in Cashmere Goat Hair Follicles by RNA Sequencing
January 2016
in “
Genetics and Molecular Research
”
hair follicles differentially expressed genes DEGs RNA sequencing electron transport gene expression cell autophagy defense reactions cysteine metabolism methionine metabolism RNA polymerization MAPK signaling pathway primary follicles microRNA-target network secondary follicles keratin-associated proteins amino acid biosynthesis microRNA keratin proteins
TLDR Researchers found 617 genes that behave differently in cashmere goat hair follicles, which could help understand hair growth.
In the 2016 study by Qiao et al., researchers performed RNA sequencing on hair follicles from six cashmere goats to identify differentially expressed genes (DEGs). They found 617 DEGs, with 297 being upregulated and 320 downregulated. Upregulated genes were mainly related to electron transport and gene expression, while downregulated genes were linked to cell autophagy and defense reactions. The study highlighted that these genes are part of pathways like cysteine and methionine metabolism, RNA polymerization, and the MAPK signaling pathway, particularly enriched in primary follicles. Additionally, a microRNA-target network suggested secondary follicles' role in synthesizing keratin-associated proteins and enzymes for amino acid biosynthesis. These results enhance the understanding of hair follicle development and cycling, laying the groundwork for future research on the genetic and functional aspects of hair follicle development.
