Generation of Tβ4 Knock-In Cashmere Goat Using CRISPR/Cas9

    January 2019 in “ International journal of biological sciences ”
    Xiaocong Li, Hao Fei, Xiao Hu, Hui Wang, Bai Dai, Xiao Wang, Hao Liang, Ming Cang, Dongjun Liu
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    TLDR Researchers used CRISPR/Cas9 to create a goat with a gene that increased cashmere production by 74.5% without affecting quality.
    In 2019, researchers successfully created a Tβ4 knock-in cashmere goat by inserting the Tβ4 gene into the goat's CCR5 locus using CRISPR/Cas9 technology, without the need for screening or fluorescent markers. The genetically modified goat showed a 74.5% increase in cashmere yield while maintaining the fiber's fineness and quality. RNA-seq analysis suggested that Tβ4 may enhance hair growth by influencing vasoconstriction, angiogenesis, and vascular permeability around secondary hair follicles. This advancement has the potential to significantly improve cashmere goat breeding and increase economic efficiency.
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