Screening and Expression Validation of Key Proteins for Secondary Hair Follicle Growth in Cashmere Goats Based on iTRAQ Quantitative Proteomics Technology

    October 2024 in “ Frontiers in Veterinary Science ”
    Jiale Chang, Meng Fan-hua, Ru Zhang, Juan Feng, Yujing Liu, Junjie Zhang, Zhaomin Liu, Jiayue Liang, Hong‐Mei Xiao
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    TLDR FKBP10 and FBN2 are key proteins for hair growth in cashmere goats.
    This study used iTRAQ quantitative proteomics technology to identify key proteins involved in the growth of secondary hair follicles (SHFs) in cashmere goats. It highlighted FKBP prolyl isomerase 10 (FKBP10) and fibrillin 2 (FBN2) as crucial proteins, with albumin (ALB), collagen type I alpha 1 chain (COL1A1), and elastin (ELN) as interacting proteins. These proteins showed higher expression during the anagen phase and lower levels during telogen, particularly in the outer root sheath of SHFs. The research provides insights into the regulatory mechanisms of SHF growth, potentially aiding in enhancing cashmere yield and quality.
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