Screening and Expression Validation of Key Proteins for Secondary Hair Follicle Growth in Cashmere Goats Based on iTRAQ Quantitative Proteomics Technology

October 2024 in “ Frontiers in Veterinary Science ”

Jiale Chang, Meng Fan-hua, Ru Zhang, Juan Feng, Yujing Liu, Junjie Zhang, Zhaomin Liu, Jiayue Liang, Hong‐Mei Xiao

iTRAQ quantitative proteomics secondary hair follicles FKBP prolyl isomerase 10 fibrillin 2 albumin collagen type I alpha 1 chain elastin anagen phase telogen phase outer root sheath iTRAQ SHFs FKBP10 FBN2 ALB COL1A1 ELN

Studysummary This study identified key proteins, FKBP10 and FBN2, that promote the growth cycle of secondary hair follicles in cashmere goats, with higher expression in the anagen phase, offering insights into mechanisms potentially enhancing cashmere yield and quality.

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This study used iTRAQ quantitative proteomics technology to identify key proteins involved in the growth of secondary hair follicles (SHFs) in cashmere goats. It highlighted FKBP prolyl isomerase 10 (FKBP10) and fibrillin 2 (FBN2) as crucial proteins, with albumin (ALB), collagen type I alpha 1 chain (COL1A1), and elastin (ELN) as interacting proteins. These proteins showed higher expression during the anagen phase and lower levels during telogen, particularly in the outer root sheath of SHFs. The research provides insights into the regulatory mechanisms of SHF growth, potentially aiding in enhancing cashmere yield and quality.

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