Multi-Omics Analysis of Functional Substances and Expression Verification in Cashmere Fineness

November 2023 in “ BMC genomics ”

Yanan Xu, Yu Zhang, Yuting Qin, Min Gu, Rui Chen, Yanyan Sun, Yanzhi Wu, Qian Li, Yan Qiao, Xiaowei Wang, Qiu Zhang, Lingchao Kong, S.L. Li, Zeying Wang

skin tissues transcriptomics translatomics proteomics metabolomics arachidonic acid metabolic pathway PLA2G12A KRT79 prostaglandin B2 skin gene expression analysis protein synthesis analysis protein analysis metabolite analysis arachidonic acid pathway keratin 79

Studysummary Using a multi-omics analysis, this study identified key regulators like PLA2G12A, KRT79, and prostaglandin B2 that influence cashmere fineness, providing crucial data for understanding the molecular mechanisms behind this trait in Liaoning cashmere goats.

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This study used a multi-omics approach to identify key regulators of cashmere fineness in Liaoning cashmere goats by analyzing skin tissues from 12 goats (6 coarse and 6 fine cashmere types). The integrated analysis included transcriptomics, translatomics, proteomics, and metabolomics, revealing significant terms such as multicellular organismal process, immune system process, and extracellular region, with a focus on the arachidonic acid metabolic pathway. Key regulators identified include PLA2G12A, KRT79, and prostaglandin B2, with KRT79 showing a positive regulatory effect on cashmere fineness. These findings provide valuable data for understanding the molecular mechanisms behind cashmere fineness and could inform future breeding programs.

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