Multi-Omics Analysis of Functional Substances and Expression Verification in Cashmere Fineness

    November 2023 in “ BMC genomics ”
    Yanan Xu, Yu Zhang, Yuting Qin, Min Gu, Rui Chen, Yanyan Sun, Yanzhi Wu, Qian Li, Yan Qiao, Xiaowei Wang, Qiu Zhang, Lingchao Kong, S.L. Li, Zeying Wang
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    TLDR The study concluded that the arachidonic acid pathway and the protein KRT79 play a role in determining the fineness of cashmere.
    This study used a multi-omics approach to identify key regulators of cashmere fineness in Liaoning cashmere goats by analyzing skin tissues from 12 goats (6 coarse and 6 fine cashmere types). The integrated analysis included transcriptomics, translatomics, proteomics, and metabolomics, revealing significant terms such as multicellular organismal process, immune system process, and extracellular region, with a focus on the arachidonic acid metabolic pathway. Key regulators identified include PLA2G12A, KRT79, and prostaglandin B2, with KRT79 showing a positive regulatory effect on cashmere fineness. These findings provide valuable data for understanding the molecular mechanisms behind cashmere fineness and could inform future breeding programs.
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