Multi-Omics Analysis of Functional Substances and Expression Verification in Cashmere Fineness

November 2023 in “ BMC genomics ”

Yanan Xu, Yu Zhang, Yuting Qin, Min Gu, Rui Chen, Yanyan Sun, Yanzhi Wu, Qian Li, Yan Qiao, Xiaowei Wang, Qiu Zhang, Lingchao Kong, S.L. Li, Zeying Wang

skin tissues transcriptomics translatomics proteomics metabolomics arachidonic acid metabolic pathway PLA2G12A KRT79 prostaglandin B2 skin gene expression analysis protein synthesis analysis protein analysis metabolite analysis arachidonic acid pathway keratin 79

TLDR The study concluded that the arachidonic acid pathway and the protein KRT79 play a role in determining the fineness of cashmere.

This study used a multi-omics approach to identify key regulators of cashmere fineness in Liaoning cashmere goats by analyzing skin tissues from 12 goats (6 coarse and 6 fine cashmere types). The integrated analysis included transcriptomics, translatomics, proteomics, and metabolomics, revealing significant terms such as multicellular organismal process, immune system process, and extracellular region, with a focus on the arachidonic acid metabolic pathway. Key regulators identified include PLA2G12A, KRT79, and prostaglandin B2, with KRT79 showing a positive regulatory effect on cashmere fineness. These findings provide valuable data for understanding the molecular mechanisms behind cashmere fineness and could inform future breeding programs.

View this study on bmcgenomics.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Keratin 79 Is a PPARA Target That Is Highly Expressed by Liver Damage

1 citations, January 2023 in “Biochemical and biophysical research communications”

Keratin 79 is linked to liver damage and may help diagnose liver diseases.

research Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

20 citations, October 2017 in “Stem Cell Reports”

Alkaline Ceramidase 1 prevents early hair loss in mice by keeping hair follicle stem cells balanced.

research Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle

18 citations, July 2016 in “Genetica”

BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.

research Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration

60 citations, November 2013 in “Development”

Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.

research The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias

53 citations, October 2012 in “The FASEB Journal”

Bimatoprost, a glaucoma medication, may also help treat hair loss.

A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations, August 2011 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

research Characterization of an In Vivo Model for the Study of Eyelash Biology and Trichomegaly: Mouse Eyelash Morphology, Development, Growth Cycle, and Anagen Prolongation by Bimatoprost

35 citations, March 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

The study showed that mouse eyelashes can be used to study eyelash growth and that bimatoprost makes them longer and more numerous.

research Characterization and Expression Analysis of KAP7.1 and KAP8.2 Genes in Liaoning New-Breeding Cashmere Goat Hair Follicles

48 citations, February 2010 in “Molecular biology reports”

KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.

research Prostaglandin Metabolism in Human Hair Follicle

65 citations, August 2007 in “Experimental Dermatology”

Human hair follicles can make and process prostaglandins, which may affect hair growth.

Related Community Posts Join

6 / 1000+ results

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 95 upvotes 4 weeks ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community Dutasteride 4.5 months really struggling what should I do

in Finasteride/Dutasteride 18 upvotes 1 month ago

The user has been on dutasteride for 4.5 months after switching from finasteride due to hair thinning, and is experiencing significant hair loss despite also using minoxidil and microneedling. Many responses suggest that dutasteride takes time to show results, often requiring patience for up to a year or more, and recommend not stopping finasteride abruptly to avoid shedding.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 8 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

in Research 487 upvotes 4 weeks ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 2 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 6 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

Related Research

1 / 1 results

10× Genomics Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research 10× Genomics Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

1 citations, November 2020 in “Research Square (Research Square)”

The study found specific skin cells and genes that may affect the quality of cashmere in Liaoning Cashmere Goats.