TLDR The study concluded that the arachidonic acid pathway and the protein KRT79 play a role in determining the fineness of cashmere.
This study used a multi-omics approach to identify key regulators of cashmere fineness in Liaoning cashmere goats by analyzing skin tissues from 12 goats (6 coarse and 6 fine cashmere types). The integrated analysis included transcriptomics, translatomics, proteomics, and metabolomics, revealing significant terms such as multicellular organismal process, immune system process, and extracellular region, with a focus on the arachidonic acid metabolic pathway. Key regulators identified include PLA2G12A, KRT79, and prostaglandin B2, with KRT79 showing a positive regulatory effect on cashmere fineness. These findings provide valuable data for understanding the molecular mechanisms behind cashmere fineness and could inform future breeding programs.
Cited in this study
8 / 8 results
1 citations
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April 2023 in “Biochemical and biophysical research communications” Keratin 79 is linked to liver damage and may help diagnose liver diseases.
18 citations
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July 2016 in “Genetica” BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.
60 citations
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December 2013 in “Development” Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.
53 citations
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October 2012 in “The FASEB Journal” Bimatoprost, a glaucoma medication, may also help treat hair loss.
81 citations
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May 2012 in “Journal of The American Academy of Dermatology” Latanoprost 0.1% may effectively treat hair loss.
35 citations
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March 2010 in “British journal of dermatology/British journal of dermatology, Supplement” The study showed that mouse eyelashes can be used to study eyelash growth and that bimatoprost makes them longer and more numerous.
48 citations
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February 2010 in “Molecular biology reports” KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.
65 citations
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August 2007 in “Experimental Dermatology” Human hair follicles can make and process prostaglandins, which may affect hair growth.
1 citations
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November 2020 in “Research Square (Research Square)” The study found specific skin cells and genes that may affect the quality of cashmere in Liaoning Cashmere Goats.