10× Genomics Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

    November 2020 in “ Research Square (Research Square) ”
    Yuanyuan Zheng, Yanru Wang, Taiyu Hui, Yanan Xu, Yu Zhang, Zeying Wang, He Tian, Wei Wang, Cong Yao, Song Guo, Rina Wu, Xingtang Dou, Xinghui Zhang, Yongwei Zhu, Dan Guo, Youngho Chang, Zhixian Bai, Jiaming Sun, Weidong Cai, Xinjiang Zhang, Min Gu, Yuting Qin, Man Bai, Yixing Fan, Bai Wenlin
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    Studysummary This study identified genes that may regulate cashmere fineness in Liaoning Cashmere Goats by analyzing skin cell types and exploring gene expression in secondary hair follicle dermal papilla cells. Our plain-language summary of this paper — not a Tressless recommendation.
    Three years ago, a study used single-cell RNA sequencing and computational models to identify 13 skin cell types in Liaoning Cashmere Goats, with a focus on understanding the cells that contribute to cashmere fineness. The study found that Secondary hair follicle dermal papilla cells (SDPCs) play a significant role in cashmere growth and density. Two genes, ACTA2 and COL1A1, were identified as highly expressed in SDPCs, with ACTA2 being a marker gene for these cells. Another gene, CXCL8, showed differential expression in coarse and fine types of Liaoning Cashmere Goats. The study suggested that COL1A1 may regulate skin development and CXCL8 may influence cashmere fineness. These findings could provide new insights into the mechanisms of cashmere growth and fineness regulation.
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